FUB-144

FUB-144
Legal status
Legal status	CA: Schedule II; DE: NpSG (Industrial and scientific use only); UK: Class B; US: Schedule I;
Identifiers
	IUPAC name [1-(4-Fluorobenzyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone;
CAS Number	2185863-15-2 ;
PubChem CID	118796439;
ChemSpider	30646792;
UNII	IWY4W66OKW;
CompTox Dashboard (EPA)	DTXSID201016907 ;
Chemical and physical data
Formula	C23H24FNO
Molar mass	349.449 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1ccc(cc1)Cn1cc(c2c1cccc2)C(=O)C1C(C1(C)C)(C)C;
	InChI InChI=1S/C23H24FNO/c1-22(2)21(23(22,3)4)20(26)18-14-25(19-8-6-5-7-17(18)19)13-15-9-11-16(24)12-10-15/h5-12,14,21H,13H2,1-4H3; Key:UXOFEILQVZFLRH-UHFFFAOYSA-N;

FUB-144 (also known as FUB-UR-144) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor^[1] and has been sold online as a designer drug.^[2] It is an analogue of UR-144 and XLR-11 where the pentyl chain has been replaced with fluorobenzyl.

Legal status

In the United States, FUB-144 was temporarily emergency scheduled by the DEA in 2019.^[3] and made a permanent Schedule I Controlled Substance on April 7, 2022.^[4]

Sweden's public health agency suggested classifying FUB-144 as hazardous substance on March 24, 2015.^[5]

References

^ Marusich JA, Gamage TF, Zhang Y, Akinfiresoye LR, Wiley JL (October 2022). "In vitro and in vivo pharmacology of nine novel synthetic cannabinoid receptor agonists". Pharmacology, Biochemistry, and Behavior. 220 173467. doi:10.1016/j.pbb.2022.173467. PMC 9837865. PMID 36154844.
^ "FUB-144". Southern Association of Forensic Scientists. Archived from the original on 27 September 2015. Retrieved 23 July 2015.
^ "Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I". Federal Register. 16 April 2019.
^ "Schedules of Controlled Substances: Placement of 5F-EDMB-PINACA, 5FMDMB-PICA, FUB-AKB48, 5F-CUMYLPINACA, and FUB-144 in Schedule I" (PDF). Federal Register. 87 (67). 7 April 2022.
^ "Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara". Folkhälsomyndigheten. Retrieved 23 July 2015.

[Marusich_2022-1] Marusich JA, Gamage TF, Zhang Y, Akinfiresoye LR, Wiley JL (October 2022). "In vitro and in vivo pharmacology of nine novel synthetic cannabinoid receptor agonists". Pharmacology, Biochemistry, and Behavior. 220 173467. doi:10.1016/j.pbb.2022.173467. PMC 9837865. PMID 36154844.

[2] "FUB-144". Southern Association of Forensic Scientists. Archived from the original on 27 September 2015. Retrieved 23 July 2015.

[fedreg-Apr-2019-3] "Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I". Federal Register. 16 April 2019.

[4] "Schedules of Controlled Substances: Placement of 5F-EDMB-PINACA, 5FMDMB-PICA, FUB-AKB48, 5F-CUMYLPINACA, and FUB-144 in Schedule I" (PDF). Federal Register. 87 (67). 7 April 2022.

[5] "Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara". Folkhälsomyndigheten. Retrieved 23 July 2015.

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Legal status

See also

References