Somatostatin receptor

Image showing somatostatin biochemical pathway complete with target cell somatostatin receptor
somatostatin receptor 1
Identifiers
SymbolSSTR1
NCBI gene6751
HGNC11330
OMIM182451
RefSeqNM_001049
UniProtP30872
Other data
LocusChr. 14 q13
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somatostatin receptor 2
Identifiers
SymbolSSTR2
NCBI gene6752
HGNC11331
OMIM182452
RefSeqNM_001050
UniProtP30874
Other data
LocusChr. 17 q24
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somatostatin receptor 3
Identifiers
SymbolSSTR3
NCBI gene6753
HGNC11332
OMIM182453
RefSeqNM_001051
UniProtP32745
Other data
LocusChr. 22 q13.1
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somatostatin receptor 4
Identifiers
SymbolSSTR4
NCBI gene6754
HGNC11333
OMIM182454
RefSeqNM_001052
UniProtP31391
Other data
LocusChr. 20 p11.2
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somatostatin receptor 5
Identifiers
SymbolSSTR5
NCBI gene6755
HGNC11334
OMIM182455
RefSeqNM_001053
UniProtP35346
Other data
LocusChr. 16 p13.3
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Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.[1]

There are five known somatostatin receptors:[2] SST1 and SST4 are potential targets for the treatment of Alzheimer's disease.[3]

All are G protein-coupled seven transmembrane receptors.

References

  1. ^ Lou L (2016). Principles of Neurobiology. New York, NY: Garland Science, Taylor and Francis Group. pp. 109–110. ISBN 978-0-8153-4494-0.
  2. ^ Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE (1995). "Classification and nomenclature of somatostatin receptors". Trends Pharmacol. Sci. 16 (3): 86–8. doi:10.1016/S0165-6147(00)88988-9. PMID 7792934.
  3. ^ Nilsson P, et al. Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain. Journal of Alzheimer’s Disease 2025; 109 (2): 651. doi:10.1177/13872877251392782
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