5-HT2A受体

5-HT2A受体
标识符
代号	HTR2A、5-HT2A受體
扩展标识	OMIM：182135；MGI：109521；HomoloGene：68073；GeneCards：HTR2A；OMA：HTR2A - orthologs
基因位置（人类） 染色体 13號染色體[1] 基因座 13q14.2 起始 46,831,546 bp[1] 终止 46,897,076 bp[1]
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in buccal mucosa cell frontal pole Brodmann area 23 BA46 无数据 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本體 分子功能 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding G protein-coupled receptor activity virus receptor activity signal transducer activity G-protein alpha-subunit binding G protein-coupled serotonin receptor activity serotonin binding neurotransmitter receptor activity 血浆蛋白结合 大分子复合物结合 細胞組分 細胞質 integral component of membrane 细胞质基质 cell projection 膜 cell body fiber integral component of plasma membrane dendritic shaft 轴突 soma caveola cytoplasmic vesicle 细胞膜 树突 glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane 生物學過程 detection of mechanical stimulus involved in sensory perception of pain release of sequestered calcium ion into cytosol regulation of dopamine secretion phospholipase C-activating serotonin receptor signaling pathway urinary bladder smooth muscle contraction positive regulation of MAP kinase activity behavioral response to cocaine positive regulation of cytosolic calcium ion concentration positive regulation of kinase activity positive regulation of phosphatidylinositol biosynthetic process 老化 cellular calcium ion homeostasis 细胞死亡 記憶 activation of phospholipase C activity detection of temperature stimulus involved in sensory perception of pain protein localization to cytoskeleton 睡眠 positive regulation of vasoconstriction positive regulation of cell population proliferation negative regulation of potassium ion transport positive regulation of ERK1 and ERK2 cascade artery smooth muscle contraction positive regulation of peptidyl-tyrosine phosphorylation 病毒进入 phosphatidylinositol 3-kinase signaling 痛覺 temperature homeostasis viral process positive regulation of fat cell differentiation positive regulation of glycolytic process negative regulation of synaptic transmission, glutamatergic 訊息傳遞 化学性突触传递 serotonin receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway 动物行为 regulation of synaptic vesicle exocytosis G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 来源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 3356 15558 Ensembl ENSG00000102468 ENSMUSG00000034997 UniProt P28223 P35363 mRNA序列 NM_001165947 ​NM_000621 ​NM_001378924 NM_172812 蛋白序列 NP_000612 ​NP_001159419 ​NP_001365853 NP_766400 基因位置 Chr 13：46.83 – 46.9 Mb 无数据 PubMed查询 [2] [3]
维基数据
檢視/編輯人類 檢視/編輯小鼠

5-HT_2A受体是5-HT₂受體的一个亚型，属于5-羟色胺（血清素）受体的一种，它是一种G蛋白偶联受体（GPCR）。^[4]

它是LP-12、​LP-44、血清素、5-甲氧基色胺、​8-OH-DPAT等药物的标靶。

• 醫學主題詞表（MeSH）：5-HT_2A+Receptor
• Human HTR2A genome location and HTR2A gene details page in the UCSC Genome Browser.
• PDB中UniProt可用的所有結構信息之概述：P28223 (5-hydroxytryptamine receptor 2A) 在PDBe-KB。