ACY1

ACY1
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	1Q7L
标识符
代号	ACY1
扩展标识	OMIM：104620；MGI：87913；HomoloGene：110440；GeneCards：ACY1；OMA：ACY1 - orthologs
基因位置（人类）
染色体	3號染色體
终止	51,989,197 bp
基因位置（小鼠）
染色体	小鼠9号染色体
终止	106,315,518 bp
RNA表达模式
	Top expressed in
	right lobe of liver; ; human kidney; ; mucosa of transverse colon; ; right adrenal gland; ; right adrenal cortex; ; muscle of thigh; ; left adrenal gland;
	Top expressed in
	right kidney; ; human kidney; ; crypt of lieberkuhn of small intestine; ; left lobe of liver;
	查阅更多表达数据
	查阅更多表达数据
基因本體
分子功能	血浆蛋白结合; 水解酶活性; metallopeptidase activity; 金屬離子結合; aminoacylase activity; 相同蛋白质结合;
細胞組分	細胞質; 细胞质基质; 外排體;
生物學過程	xenobiotic metabolic process; cellular amino acid metabolic process; 代謝; 蛋白酶解;
	来源：Amigo / QuickGO
直系同源
	95
	109652
	ENSG00000243989
	ENSMUSG00000023262
	Q03154
	Q99JW2
	NM_001198898; NM_000666; NM_001198895; NM_001198896; NM_001198897
	NM_001276442; NM_025371
	NP_000657; NP_001185824; NP_001185825; NP_001185826; NP_001185827
	NP_001263371; NP_079647
	维基数据
檢視/編輯人類	檢視/編輯小鼠

ACY1（氨基酰化酶1，英語：Aminoacylase 1，缩写ACY-1，也称为附睾管腔蛋白-S-5，英語：Epididymis Luminal Protein-S-5，缩写HEL-S-5），化学式为：C₂₀₆₅H₃₁₅₁O₅₉₈N₅₆₃S₁₄Zn₂^[5]，是一个人类基因 ACY1 编码的蛋白质，是一种位于胞质溶胶的二聚体锌结合水解酶，EC编号3.5.1.14，位于人类第3号染色体上3p21.1区域。^[6]^[7]^[8]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000243989 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000023262 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Expasy - ProtParam. web.expasy.org. [2025-10-16].
^ Miller YE, Drabkin H, Jones C, Fisher JH. Human aminoacylase-1: cloning, regional assignment to distal chromosome 3p21.1, and identification of a cross-hybridizing sequence on chromosome 18. Genomics. Sep 1990, 8 (1): 149–154. PMID 1707030. doi:10.1016/0888-7543(90)90237-O.
^ Voss R, Lerer I, Povey S, Solomon E, Bobrow M. Confirmation and further regional assignment of aminoacylase 1 (acy-1) on human chromosome 3 using a simplified detection method. Annals of Human Genetics. Jul 1980, 44 (Pt 1): 1–9. PMID 6948533. S2CID 21566170. doi:10.1111/j.1469-1809.1980.tb00940.x.
^ Entrez Gene: ACY1 aminoacylase 1.

外部链接

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000243989 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000023262 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Expasy - ProtParam. web.expasy.org. [2025-10-16].

[pmid1707030-6] Miller YE, Drabkin H, Jones C, Fisher JH. Human aminoacylase-1: cloning, regional assignment to distal chromosome 3p21.1, and identification of a cross-hybridizing sequence on chromosome 18. Genomics. Sep 1990, 8 (1): 149–154. PMID 1707030. doi:10.1016/0888-7543(90)90237-O.

[pmid6948533-7] Voss R, Lerer I, Povey S, Solomon E, Bobrow M. Confirmation and further regional assignment of aminoacylase 1 (acy-1) on human chromosome 3 using a simplified detection method. Annals of Human Genetics. Jul 1980, 44 (Pt 1): 1–9. PMID 6948533. S2CID 21566170. doi:10.1111/j.1469-1809.1980.tb00940.x.

[entrez-8] Entrez Gene: ACY1 aminoacylase 1.

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水解酶类：碳-氮非肽（EC 3.5）
3.5.1：线性酰胺/ 酰胺水解酶	天冬酰胺酶谷氨酰胺酶脲酶生物素酶氨基酰化酶 ACY1 天冬氨酸酰酶 ACY3 神经酰胺酶天门冬酰胺氨基葡萄糖酶脂肪酰胺水解酶组蛋白脱乙酰酶 Sirtuin：1、2、3、5、6、7
3.5.2：环状酰胺/ 酰胺水解酶	丙二酰脲酶 β-内酰胺酶二氢乳清酸酶
3.5.3：线性脒/ 脲水解酶	精氨酸酶鲱精胺酶蛋白质-精氨酸脱亚氨酶
3.5.4：环状脒/ 氨基水解酶	鸟嘌呤脱氨酶腺苷脫氨酶 AMP脱氨酶肌苷单磷酸合酶 DCMP脱氨酶 GTP环水解酶I 胞苷脱氨酶活化诱导性胞苷脱氨酶
3.5.5：腈/ 氨基水解酶	腈水解酶
3.5.99：其他	核黄素酶硫胺酶II
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3/4/5-6