钙蛋白酶9

钙蛋白酶9
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	1ZIV、2P0R
标识符
代号	CAPN9
扩展标识	OMIM：606401；MGI：1920897；HomoloGene：38208；GeneCards：CAPN9；OMA：CAPN9 - orthologs
基因位置（人类）
染色体	1號染色體
终止	230,802,003 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	125,345,470 bp
RNA表达模式
	Top expressed in
	C1 segment; ; mucosa of transverse colon; ; body of stomach; ; mucosa of ileum; ; olfactory zone of nasal mucosa; ; bronchial epithelial cell; ; pancreatic ductal cell; ; right lung;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; lumbar spinal ganglion; ; left colon;
	查阅更多表达数据
	; ;
	查阅更多表达数据
基因本體
分子功能	calcium ion binding; 肽酶活性; 半胱氨酸型肽酶活性; 水解酶活性; 金屬離子結合; calcium-dependent cysteine-type endopeptidase activity;
細胞組分	胞內; 細胞質; 细胞组件;
生物學過程	消化作用; 蛋白酶解; sarcomere organization;
	来源：Amigo / QuickGO
直系同源
	10753
	73647
	ENSG00000135773
	ENSMUSG00000031981
	O14815
	Q9D805
	NM_006615; NM_016452; NM_001319676
	NM_023709
	NP_001306605; NP_006606; NP_057536
	NP_076198
	维基数据
檢視/編輯人類	檢視/編輯小鼠

钙蛋白酶9（英语：Calpain-9）是一种在人类中由CAPN9基因编码的蛋白质。^[5]^[6]^[7]

钙蛋白酶是普遍存在的、保守的钙依赖性半胱氨酸蛋白酶家族。钙蛋白酶是由不变的小亚基和可变的大亚基组成的异二聚体。大亚基具有半胱氨酸蛋白酶结构域，而两个亚基都具有钙结合结构域。钙蛋白酶与神经退行性过程有关，因为它们的激活可以由钙流入和氧化应激触发。由该基因编码的蛋白质主要在胃和小肠中表达，并可能在消化道中具有特殊功能。该基因被认为与胃癌有关。该基因可编码不同亚型的多个可变剪接转录物变体。^[7]

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000135773 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031981 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. May 1998, 379 (2): 175–184. PMID 9524069. S2CID 37483841. doi:10.1515/bchm.1998.379.2.175.
^ Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res. Jul 2000, 91 (5): 459–63. PMC 5926377 . PMID 10835488. doi:10.1111/j.1349-7006.2000.tb00967.x.
^ ^7.0 ^7.1 Entrez Gene: CAPN9 calpain 9. [2023-01-28]. （原始内容存档于2010-12-05）.

延伸阅读

Huang Y, Wang KK. The calpain family and human disease. Trends in Molecular Medicine. 2001, 7 (8): 355–362. PMID 11516996. doi:10.1016/S1471-4914(01)02049-4.
Suzuki K, Sorimachi H, Yoshizawa T, et al. Calpain: novel family members, activation, and physiologic function. Biol. Chem. Hoppe-Seyler. 1996, 376 (9): 523–9. PMID 8561910. doi:10.1515/bchm3.1995.376.9.523.
Davis TL, Walker JR, Finerty PJ, et al. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J. Mol. Biol. 2007, 366 (1): 216–229. PMID 17157313. doi:10.1016/j.jmb.2006.11.037.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Lee HJ, Tomioka S, Kinbara K, et al. Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. Arch. Biochem. Biophys. 1999, 362 (1): 22–31. PMID 9917325. doi:10.1006/abbi.1998.1021.

外部链接

Human CAPN9 genome location and CAPN9 gene details page in the UCSC Genome Browser.
The MEROPS online database for peptidases and their inhibitors: C02.006 Archive.today的存檔，存档日期2012-12-23
PDB中UniProt可用的所有結構信息之概述：O14815 (Human Calpain-9 (CAPN9)) 在PDBe-KB。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000135773 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031981 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9524069-5] Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. May 1998, 379 (2): 175–184. PMID 9524069. S2CID 37483841. doi:10.1515/bchm.1998.379.2.175.

[pmid10835488-6] Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res. Jul 2000, 91 (5): 459–63. PMC 5926377 . PMID 10835488. doi:10.1111/j.1349-7006.2000.tb00967.x.

[entrez-7] 7.0 ^7.1 Entrez Gene: CAPN9 calpain 9. [2023-01-28]. （原始内容存档于2010-12-05）.

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蛋白酶类：半胱氨酸蛋白酶类（EC 3.4.22)
胱天蛋白酶	胱天蛋白酶1 胱天蛋白酶2 胱天蛋白酶3 胱天蛋白酶4 胱天蛋白酶5 胱天蛋白酶6 胱天蛋白酶7 胱天蛋白酶8 胱天蛋白酶9 胱天蛋白酶10 胱天蛋白酶11 胱天蛋白酶12 胱天蛋白酶13 胱天蛋白酶14
来自果实	木瓜蛋白酶无花果蛋白酶鳳梨蛋白酶猕猴桃蛋白酶
钙蛋白酶	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
组织蛋白酶	B C F H K L1/L2 O S T W Z
其它	梭菌蛋白酶癌性促凝物质分离酶自噬蛋白酶 Cruzipain 3C样蛋白酶牙龈蛋白酶R 牙龈蛋白酶K
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3/4/5-6