DCLK1

DCLK1
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	1MFW、1MG4、1UF0
标识符
代号	DCLK1
扩展标识	OMIM：604742；MGI：1330861；HomoloGene：130530；GeneCards：DCLK1；OMA：DCLK1 - orthologs
基因位置（人类）
染色体	13號染色體
终止	36,131,382 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	55,446,489 bp
RNA表达模式
	Top expressed in
	frontal pole; ; Brodmann area 23; ; pars reticulata;
	Top expressed in
	Rostral migratory stream; ; vestibular sensory epithelium;
	查阅更多表达数据
	; ;
	查阅更多表达数据
基因本體
分子功能	轉移酶活性; 蛋白激酶活性; 核苷酸結合; 激酶活性; ATP結合; 蛋白质丝氨酸/苏氨酸激酶活性;
細胞組分	integral component of plasma membrane; 胞內; 突触后致密物质;
生物學過程	细胞分化; axonogenesis; dendrite morphogenesis; 磷酸化; response to virus; neuron migration; 神經系統的發育; multicellular organism development; endosomal transport; protein phosphorylation; central nervous system development; brain development; axon extension; forebrain development; central nervous system projection neuron axonogenesis; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction; neuron projection morphogenesis;
	来源：Amigo / QuickGO
直系同源
	9201
	13175
	ENSG00000133083
	ENSMUSG00000027797
	O15075
	Q9JLM8
NM_001195415; NM_001195416; NM_001195430; NM_004734; NM_001330071;
	NM_001330072
NM_001111051; NM_001111052; NM_001111053; NM_001195538; NM_001195539;
	NM_001195540; NM_019978; NM_001357466; NM_001357468; NM_001357469; NM_001357475; NM_001357476
NP_001182344; NP_001182345; NP_001182359; NP_001317000; NP_001317001;
	NP_004725
NP_001104521; NP_001104522; NP_001104523; NP_001182467; NP_001182468;
	NP_001182469; NP_064362; NP_001344395; NP_001344397; NP_001344398; NP_001344404; NP_001344405
	维基数据
檢視/編輯人類	檢視/編輯小鼠

双肾上腺皮质激素样激酶1（英語：Doublecortin like kinase 1，缩写DCLK1）是一种丝氨酸/苏氨酸激酶，在人类基因组中由DCLK1 基因编码^[5]^[6]^[7]，在肠道上皮的丛细胞（Tuft cell）中大量表达，也是胃肠道肿瘤干细胞的分子标志物^[8]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000133083 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027797 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. J Hum Genet. Oct 1998, 43 (3): 169–77. PMID 9747029. doi:10.1007/s100380050063 .
^ Sossey-Alaoui K, Srivastava AK. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). Genomics. May 1999, 56 (1): 121–6. PMID 10036192. doi:10.1006/geno.1998.5718.
^ Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1.
^ DCLK1的空间结构和理化性质分析. 生物信息学. 2018-12-11, 16 (4): 231–238. doi:10.12113/j.issn.1672-5565.201712002.

延伸阅读

Nagase T, Ishikawa K, Nakajima D, et al. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.. DNA Res. 1997, 4 (2): 141–50. PMID 9205841. doi:10.1093/dnares/4.2.141 .
Matsumoto N, Pilz DT, Ledbetter DH. Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS).. Genomics. 1999, 56 (2): 179–83. PMID 10051403. doi:10.1006/geno.1998.5673.
Lin PT, Gleeson JG, Corbo JC, et al. DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization.. J. Neurosci. 2001, 20 (24): 9152–61. PMID 11124993. doi:10.1523/JNEUROSCI.20-24-09152.2000 .
Burgess HA, Reiner O. Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities.. J. Biol. Chem. 2002, 277 (20): 17696–705. PMID 11884394. doi:10.1074/jbc.M111981200 .
Kim MH, Derewenda U, Devedjiev Y, et al. Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase.. Acta Crystallogr. D. 2003, 59 (Pt 3): 502–5. PMID 12595708. doi:10.1107/S0907444903000027.
Kim MH, Cierpicki T, Derewenda U, et al. The DCX-domain tandems of doublecortin and doublecortin-like kinase.. Nat. Struct. Biol. 2003, 10 (5): 324–33. PMID 12692530. doi:10.1038/nsb918.
Seet LF, Liu N, Hanson BJ, Hong W. Endofin recruits TOM1 to endosomes.. J. Biol. Chem. 2004, 279 (6): 4670–9. PMID 14613930. doi:10.1074/jbc.M311228200 .
Ballif BA, Villén J, Beausoleil SA, et al. Phosphoproteomic analysis of the developing mouse brain.. Mol. Cell. Proteomics. 2005, 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200 .

外部链接

PDB中UniProt可用的所有結構信息之概述：O15075 (Serine/threonine-protein kinase DCLK1) 在PDBe-KB。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000133083 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027797 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9747029-5] Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. J Hum Genet. Oct 1998, 43 (3): 169–77. PMID 9747029. doi:10.1007/s100380050063 .

[pmid10036192-6] Sossey-Alaoui K, Srivastava AK. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). Genomics. May 1999, 56 (1): 121–6. PMID 10036192. doi:10.1006/geno.1998.5718.

[entrez-7] Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1.

[8] DCLK1的空间结构和理化性质分析. 生物信息学. 2018-12-11, 16 (4): 231–238. doi:10.12113/j.issn.1672-5565.201712002.

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