LY-255582

LY-255582
首选IUPAC名
3-{(3R,4R)-1-[(3S)-3-Cyclohexyl-3-hydroxypropyl]-3,4-dimethylpiperidin-4-yl}phenol
识别
CAS号 119193-09-8
PubChem 9906198
ChemSpider 8081850
SMILES
 
  • C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CC[C@@H](C3CCCCC3)O
InChI
 
  • 1/C22H35NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h6,9-10,15,17-18,21,24-25H,3-5,7-8,11-14,16H2,1-2H3/t17-,21-,22+/m0/s1
InChIKey LVVHEFJXPXAUDD-BULFRSBZBD
性质
化学式 C22H35NO2
摩尔质量 345.52 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

LY-255582是一种含氮有机化合物，化学式为C22H35NO2，属于苯基哌啶类化合物，可作为阿片类受体的非选择性受体拮抗剂[1]，在肥胖实验大鼠中具有减肥作用[2]。

参考文献

  1. ^ Dhaher R, et al. Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats.. Alcohol (Fayetteville, N.Y.). Feb 2012, 46 (1): 17–27. PMC 4581853 可免费查阅. PMID 21962974. doi:10.1016/j.alcohol.2011.08.011. 
  2. ^ Shaw WN, et al. The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat.. International Journal of Obesity. Jun 1991, 15 (6): 387–95. PMID 1653188. 
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