Upjohn
| The Upjohn Company | |
|---|---|
 | |
| 公司類型 | 公司  |
| 公司結局 | 与Pharmacia合并为Pharmacia & Upjohn |
| 後繼機構 | Pharmacia & Upjohn 晖致（Viatris） |
| 成立 | 1886年 |
| 结束 | 1995年 |
| 總部 | 美国密歇根州波蒂奇 |
| 产业 | 制药产业 |
Upjohn是一家美国制药公司，1886年由威廉·E·厄普约翰在密歇根州黑斯廷斯成立[1]，1995年与瑞典Pharmacia公司合并为Pharmacia & Upjohn，现为輝瑞公司所有。
历史
1976年，公司的三位科学家开发了Upjohn双羟基化反应[2]。
产品
四位数
| 名称 | CAS号 | 分子式 | 化学结构 |
|---|---|---|---|
| 苄非他明 （U-0441） |
156-08-1 | C 17H 21N |
|
| U-0882 | 310-35-0 | C 18H 21NO 2 |
|
| 敌鼠 （U-1363） |
82-66-6 | C 23H 16O 3 |
|
| 羧雌醚 （U-2911） |
1755-52-8 | C 17H 22O 3 |
|
| U-4527 | 66-81-9 | C 15H 23NO 4 |
|
| U-5956 | 480-49-9 | C 35H 58O 11 |
|
| U-6040 | 76-43-7 | C 20H 29FO 3 |
|
| U-6056 | 13117-35-6 | C 13H 18N 2 |
|
| U-8113 | 1688-71-7 | C 10H 13NO |
|
| U-8344 | 66-75-1 | C 8H 11Cl 2N 3O 2 |
|
| U-8471 | 2668-66-8 | C 22H 32O 3 |
|
| U-8614 | 426-13-1 | C 22H 29FO 4 |
|
| 醋酸甲羥孕酮 （U-8839） |
71-58-9 | C 24H 34O 4 |
|
| U-8840 | 520-85-4 | C 22H 32O 3 |
|
| 2-氨基-1,1,3-三氰基-1-丙烯 （U-9189） |
868-54-2 | C 6H 4N 4 |
|
| U-9889 | 18883-66-4 | C 8H 15N 3O 7 |
|
五位数
| 名称 | CAS号 | 分子式 | 化学结构 |
|---|---|---|---|
| 林可霉素 （U-10149） |
154-21-2 | C 18H 34N 2O 6S |
|
| U-10157 | 705-62-4 | C 9H 12N 2S |
|
| 米勃龙 （U-10997）[3] |
3704-09-4 | C 20H 30O 2 |
|
| U-11000A | 1845-11-0 | C 29H 31NO 2 |
|
| U-11555A | 64-96-0 | C 28H 31NO 2 |
|
| 曲托龙 （U-11828）[3] |
3764-87-2 | C 19H 28O 2 |
|
| U-12504 | 1228-19-9 | C 13H 18ClN 3O 3S |
|
| U-17312E | 2235-90-7 | C 12H 16N 2 |
|
| U-17323 | 3801-06-7 | C 24H 31FO 5 |
|
| U-17835 | 1156-19-0 | C 14H 21N 3O 3S |
|
| 布洛芬 （U-18573） |
15687-27-1 | C 13H 18O 2 |
|
| 勃拉睾酮 （U-19763） |
1605-89-6 | C 21H 32O 2 |
|
| 吲哚克索 （U-22020） |
5034-76-4 | C 22H 19NO 2 |
|
| PNU-22394 (U-22394A) |
15923-78-1 | C 13H 16N 2 |
|
| U-22410A | 10090-61-6 | C 28H 29NO |
|
| 卡鲁睾酮 （U-22550） |
17021-26-0 | C 21H 32O 2 |
|
| U-23284 | 18771-50-1 | C 9H 16N 2O 6 |
|
| U-23469[4] | 36840-93-4 | C 26H 28O 4 |
|
| U-24568 | 21766-17-6 | C 26H 22N 2O 2 |
|
| U-26597A | 8001-95-4 | C 11H 28ClN 5O |
|
| U-28288D | 22195-34-2 | C 10H 19N 3O 2 |
|
| 2-MDP （U-23807A） |
33887-05-7 | C 16H 19NO |
|
| U-28774 | 27223-35-4 | C 20H 17ClN 2O 3 |
|
| U-29409 | 31785-60-1 | C 18H 14N 2O |
|
| U-30870 | 50303-11-2 | C 23H 31NO 2 |
|
| U-31355 | 99983-92-3 | C 11H 10ClN 3S |
|
| 阿普唑仑 （U-31889） |
28981-97-7 | C 17H 13ClN 4 |
|
| 骨化二醇 （U-32070） |
19356-17-3 | C 27H 44O 2 |
|
| U-32802A | 36735-48-5 | C 22H 23F 2NO |
|
| 三唑仑 （U-33030） |
28911-01-5 | C 17H 12Cl 2N 4 |
|
| U-35777A | 55199-71-8 | C 23H 27F 2NO 2 |
|
| U-37883A | 57568-80-6 | C 21H 35N 3O |
|
| U-41792 | 56714-70-6 | C 21H 29NO |
|
| U-42585 | 53882-12-5 | C 11H 6ClN 3O 6 |
|
| U-46619 | 56985-40-1 | C 21H 34O 4 |
|
| U-46785 | 61263-35-2 | C 23H 38O 4 |
|
| U-47109 | 67579-13-9 | C 15H 20Cl 2N 2O |
|
| U-47476A | 36192-18-4 | C 12H 18N 2 |
|
| U-47700 | 82657-23-6 | C 16H 22Cl 2N 2O |
|
| 溴朵林 （U-47931E） |
67579-24-2 | C15H21BrN2O | 
|
| U-48520 | 67579-11-7 | C 16H 23ClN 2O |
|
| 依氯那明 （U-48753） |
67450-44-6 | C 16H 22Cl 2N 2O |
|
| U-48800 | 2370977-17-4 | C 17H 24Cl 2N 2O |
|
| U-49900 | 67579-76-4 | C 18H 26Cl 2N 2O |
|
| U-50211 | 98587-47-4 | C 16H 24N 2O 2 |
|
| U-50488 | 67198-13-4 | C 19H 26Cl 2N 2O |
|
| U-51574 | PubChem CID：44269303 | C 17H 24Cl 2N 2O |
|
| U-52047 | 71628-96-1 | C 28H 31NO 10 |
|
| U-53059 | 70529-35-0 | C 18H 14F 3NO 2S |
|
| U-54669F | 72141-57-2 | C 27H 22F 4N 4O 3S |
|
| U-57700 | 102092-12-6 | C 16H 21N |
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|
| U-57930E | 79548-73-5 | C 17H 31ClN 2O 5S |
|
| U-58838 | 83701-22-8 | C 9H 15N 5O 4S |
|
| 吡前列素 （U-60257） |
79672-88-1 | C 26H 35NO 4 |
|
| U-61431F | 81845-44-5 | C 22H 36O 4 |
|
| 螺朵林 （U-62066） |
87151-85-7 | C 22H 30Cl 2N 2O 2 |
|
| U-63557A | 85666-24-6 | C 15H 11NO 3 |
|
| U-64279E | 104010-37-9 | C 19H 17N 5O 7S 3 |
|
| 阿仑替莫 （U-66444B） |
112892-81-6 | C 19H 25NO |
|
| U-69167 | 99499-40-8 | C 16H 17N 3OS 2 |
|
| U-69593 | 96744-75-1 | C 22H 32N 2O 2 |
|
| U-73122 | 112648-68-7 | C 29H 40N 2O 3 |
|
| U-73343 | 142878-12-4 | C 29H 42N 2O 3 |
|
| U-74006 | 110101-66-1 | C 38H 52N 6O 2 |
|
| U-75875 （Pnu-75875） |
112190-24-6 | C 45H 61N 7O 7 |
|
| U-77891 | 119878-31-8 | C 18H 24Br 2N 2O |
|
| U-78036 | 123742-98-3 | C 17H 11ClN 2O |
|
| U-78875 | 124423-84-3 | C 18H 17N 5O 2 |
|
| 卡折来新 （U-80244） |
119813-10-4 | C 41H 37ClN 6O 5 |
|
| U-80493 | 136816-67-6 | C 21H 30N 4O |
|
| U-81749 | 126103-94-4 | C 33H 56N 4O 4 |
|
| U-82208E | 136591-56-5 | C 20H 36N 2O 3S |
|
| U-82209E | 136591-58-7 | C 20H 36N 2O 3S |
|
| U-84569 | 130736-25-3 | C 25H 23NO 4 |
|
| U-86983 | 130736-65-1 | C 19H 18N 2O 4 |
|
| 阿替韦啶 （U-87201E） |
138540-32-6 | C 21H 25N 5O 2 |
|
| U-88779E | 149539-01-5 | C 29H 33ClN 2O 2 |
|
| U88999E | 142223-57-2 | C 29H 32F 2N 2O 2 |
|
| U-89360E | 161897-65-0 | C 28H 52N 8O 6 |
|
| U-90152 | 136817-59-9 | C 22H 28N 6O 3S |
|
| PNU-91356A （U-91356） |
152886-85-6 | C 13H 17N 3O |
|
| U-92032 | 142223-92-5 | C 30H 35F 2N 3O 2 |
|
| U-92798 | PC9891838 | C 30H 34F 2N 2O 2 |
|
| U-96988 | 149394-65-0 | C 24H 26O 3 |
|
| 普拉克索 （U-98528E） |
104632-26-0 | C 10H 17N 3S |
|
| JPC-211 （U-99194） |
82668-33-5 | C 17H 27NO 2 |
|
| U-99363 | 179556-82-2 | C 20H 27N 3O |
|
六位数
| 名称 | CAS号 | 分子式 | 化学结构 |
|---|---|---|---|
| U-100480 | 168828-58-8 | C 16H 20FN 3O 3S |
|
| U-101387 | 170858-33-0 | C 21H 27N 3O 3S |
|
| U-101958 | 170856-57-2 | C 21H 29N 3O |
|
| U-103017 | 166335-18-8 | C 28H 28N 2O 5S |
|
参考文献
- ^ Lohrstorfer, Martha; Larson, Catherine. William E. Upjohn: Person of the Century 1853 - 1932. Kalamazoo Public Library. 2002 [December 24, 2024]. （原始内容存档于May 17, 2008）.
Known by his contemporaries as a dreamer and a tinkerer, Dr. Upjohn saw a need to improve the means of administering medicine. Most medicines of the day were in fluid form, and those in pill form were often hard and insoluble. Patients were left to try to digest the bitter medicine, with no guarantee that it would dissolve in their systems effectively. Dr. Upjohn began experimenting with making better pills in the attic of his home. Eventually he invented his "friable" pill. Friable meant that the pill could easily be crushed to a powder. The pill was patented in 1885, and its reputation quickly spread within the medical community, thanks greatly to Dr. Upjohn's marketing strategy. He sent small pine boards to thousands of physicians along with samples of his rival's hard pills, and his own friable pills. He invited doctors to hammer the pills into the boards to see which one would be the most digestible. This tactic was eventually modified, but for the next 60 years, a thumb reducing an Upjohn pill to powder was used as the trademark symbol of his company, the Upjohn Pill and Granule Company, later more widely known to the world as The Upjohn Company.
- ^ VanRheenen, V.; Kelly, R.C.; Cha, D.Y. An improved catalytic OsO4 oxidation of olefins to -1,2-glycols using tertiary amine oxides as the oxidant. Tetrahedron Letters. 1976-06, 17 (23): 1973–1976. doi:10.1016/S0040-4039(00)78093-2.
- ^ 3.0 3.1 ((Lyster, S C.)), ((Duncan, G W.)). ANABOLIC, ANDROGENIC AND MYOTROPIC ACTIVITIES OF DERIVATIVES OF 7α-METHYL-19-NORTESTOSTERONE. Acta Endocrinologica. July 1963, 43 (3): 399–411. doi:10.1530/acta.0.0430399. 温哥华格式错误 (帮助)
- ^ ((Castañer, J.)), ((Hillier, K.)). U-23,469. Drugs of the Future. 1980, 5 (11): 564. ISSN 0377-8282. doi:10.1358/dof.1980.005.11.1002363.