蛋白酪氨酸磷酸酶C型受體

蛋白酪氨酸磷酸酶C型受體
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	1YGU、1YGR、5FMV、5FN6、5FN7
标识符
代号	PTPRC
扩展标识	OMIM：151460；MGI：97810；HomoloGene：2126；GeneCards：PTPRC；OMA：PTPRC - orthologs
基因位置（人类）
染色体	1號染色體
终止	198,757,476 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	138,103,446 bp
RNA表达模式
	Top expressed in
	epithelium of nasopharynx;
	Top expressed in
	tibiofemoral joint; ; stroma of bone marrow; ; right lung;
	查阅更多表达数据
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	phosphoprotein phosphatase activity; phosphatase activity; 血浆蛋白结合; transmembrane receptor protein tyrosine phosphatase activity; protein kinase binding; 水解酶活性; protein tyrosine phosphatase activity;
細胞組分	integral component of membrane; 膜; 粘着斑; 细胞膜; integral component of plasma membrane; cell surface; 脂筏模型; 外排體; external side of plasma membrane; secretory granule membrane;
生物學過程	B cell receptor signaling pathway; cell cycle phase transition; release of sequestered calcium ion into cytosol; negative regulation of protein kinase activity; bone marrow development; stem cell development; 蛋白质去磷酸化; negative regulation of cytokine-mediated signaling pathway; positive regulation of hematopoietic stem cell migration; regulation of cell cycle; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of T cell mediated cytotoxicity; cell surface receptor signaling pathway; B cell proliferation; T cell differentiation; positive regulation of B cell proliferation; defense response to virus; positive regulation of T cell proliferation; hematopoietic progenitor cell differentiation; positive regulation of antigen receptor-mediated signaling pathway; T cell receptor signaling pathway; positive regulation of stem cell proliferation; 去磷酸化; positive regulation of protein kinase activity; peptidyl-tyrosine dephosphorylation; neutrophil degranulation;
	来源：Amigo / QuickGO
直系同源
	5788
	19264
	ENSG00000081237; ENSG00000262418
	ENSMUSG00000026395
	P08575
	P06800
	NM_001267798; NM_002838; NM_080921; NM_080922
	NM_001111316; NM_001268286; NM_011210
	NP_001254727; NP_002829; NP_563578; NP_563578.2; NP_002829.3
	NP_001104786; NP_001255215; NP_035340
	维基数据
檢視/編輯人類	檢視/編輯小鼠

蛋白酪氨酸磷酸酶C型受體（英語：Protein tyrosine phosphatase, receptor type, C，縮寫：PTPRC）化学式为：C₇₈₉₆H₁₂₃₉₀O₃₁₁₃N₁₈₅₄S₄₆^[5]，是一個由PTPRC人類基因編碼的酶^[6] 蛋白酪氨酸磷酸酶C型受體又叫做45號分化簇抗原，以前曾叫白細胞常見抗原（英語：leukocyte common antigen，縮寫：LCA）。^[7]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000081237、ENSG00000262418 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000026395 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ 蛋白酪氨酸磷酸酶C型受體｜Expasy - ProtParam. web.expasy.org｜注：“该分子式基于 17 个 N-连接糖基化位点均被 Fuc₁Neu5Ac₂Gal₂GlcNAc₄Man₃（双支链完全唾液酸化结构）修饰的理论模型得出，每个修饰淨增長：C₉₀H₁₄₆N₆O₆₅. [2026-05-12]. 参数|website=值左起第18位存在零宽空格 (帮助)
^ Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc. Natl. Acad. Sci. U.S.A. September 1990, 87 (18): 7000–4 [2019-05-01]. PMC 54670 . PMID 2169617. doi:10.1073/pnas.87.18.7000. （原始内容存档于2019-10-17）.
^ Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C. （原始内容存档于2010-12-05）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000081237、ENSG00000262418 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000026395 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] 蛋白酪氨酸磷酸酶C型受體｜Expasy - ProtParam. web.expasy.org｜注：“该分子式基于 17 个 N-连接糖基化位点均被 Fuc₁Neu5Ac₂Gal₂GlcNAc₄Man₃（双支链完全唾液酸化结构）修饰的理论模型得出，每个修饰淨增長：C₉₀H₁₄₆N₆O₆₅. [2026-05-12]. 参数|website=值左起第18位存在零宽空格 (帮助)

[pmid2169617-6] Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc. Natl. Acad. Sci. U.S.A. September 1990, 87 (18): 7000–4 [2019-05-01]. PMC 54670 . PMID 2169617. doi:10.1073/pnas.87.18.7000. （原始内容存档于2019-10-17）.

[entrez-7] Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C. （原始内容存档于2010-12-05）.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

蛋白質：分化群（參見人類細胞分化群列表）
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 α β CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 （a d e i k） CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD215 CD217 CD218 （IL18R1a b） CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350