5-HT1A受体

5-HT1A受體
标识符
代号HTR1A
扩展标识OMIM109760MGI96273;HomoloGene:20148GeneCardsHTR1A;OMA:HTR1A - orthologs
直系同源
物種人類小鼠
Entrez
3350
15550
Ensembl
ENSG00000178394
ENSMUSG00000021721
UniProt
P08908
Q64264
mRNA序列
NM_000524
NM_008308
蛋白序列
NP_000515
NP_032334
基因位置Chr 5:63.96 – 63.96 MbChr 13:105.58 – 105.58 Mb
PubMed查询[3][4]
维基数据
檢視/編輯人類檢視/編輯小鼠

5-HT1A受体是血清素受体的一种,可与神经递质血清素(5-HT)结合。它可以在脑、脾和新生儿肾脏中表达。它是一种G蛋白偶联受体(GPCR),可与Gi蛋白偶联,在脑中的激活可介导超极化和突触后神经元放电率降低。人的5-HT1A受体由HTR1A基因编码。[5][6]

参考文献

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000178394 – Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000021721Ensembl, 2017年5月
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ. Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia. Genomics. November 1989, 5 (4): 940–4. PMC 3154173可免费查阅. PMID 2591972. doi:10.1016/0888-7543(89)90138-9. 
  6. ^ Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A. 

外部链接

  • 5-HT1A. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. [2008-11-24]. (原始内容存档于2012-09-02). 
  • Human HTR1A genome location and HTR1A gene details page in the UCSC Genome Browser.