7-氯色胺

7-氯色胺
臨床資料
其他名稱7-Chloro-T; 7-CT; 7-Cl-T; PAL-532; PAL532
藥物類別Serotonin receptor agonist; Serotonin releasing agent
识别信息
  • 2-(7-chloro-1H-indol-3-yl)ethanamine
CAS号3804-16-8
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
化学信息
化学式C10H11ClN2
摩尔质量194.66 g·mol−1
3D模型（JSmol）
  • C1=CC2=C(C(=C1)Cl)NC=C2CCN
  • InChI=1S/C10H11ClN2/c11-9-3-1-2-8-7(4-5-12)6-13-10(8)9/h1-3,6,13H,4-5,12H2
  • Key:QKRNGBURTLCWBQ-UHFFFAOYSA-N

7-氯色胺（7-Cl-T或7-CT，代号PAL-532）是一种血清素受體激動劑單胺釋放劑，化学式为C10H11ClN2，它是一种色胺类化合物。[1]它是浅黄色固体[2]，可由7-氯吲哚-3-甲醛和硝基甲烷反应，再经氢化铝锂还原制得。[3]

参考文献

  1. ^ Blough BE, Landavazo A, Partilla JS, Decker AM, Page KM, Baumann MH, Rothman RB. Alpha-ethyltryptamines as dual dopamine-serotonin releasers. Bioorg Med Chem Lett. October 2014, 24 (19): 4754–4758. PMC 4211607 可免费查阅. PMID 25193229. doi:10.1016/j.bmcl.2014.07.062. 
  2. ^ K. C. Nicolaou; et al. New Synthetic Technologies for the Construction of Heterocycles and Tryptamines. J. Am. Chem. Soc. 2009, 131, 10, 3690–3699. doi:10.1021/ja808692j
  3. ^ Chen, Zhihuang; et al. Room-Temperature Secondary Ammonium Salt-Catalyzed Enantioselective Halogenation via Hydrogen-Bonded Ion Pair. ACS Catalysis (2024), 14(19), 14387-14398. doi:10.1021/acscatal.4c04829.

外部链接

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